Periactin

Periactin

Cyproheptadine HCl


Periactin - Periactin Side Effects - Periactin Information


Pharmacology: Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects recommended for the symptomatic treatment of allergic disorders and pruritic dermatoses, as well as certain types of vascular headaches.




Indications: Cyproheptadine (Periactin 4mg) has a wide range of antiallergic and antipruritic activity and can be used successfully in the treatment of acute and chronic allergies and pruritus, such as: dermatitis, including neurodermatitis and neurodermatitis circumscripta, eczema, eczematoid dermatitis, dermatographism, mild local allergic reactions to insect bites, hay fever and other seasonal rhinitis, perennial allergic and vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, urticaria, including cold urticaria, angioneurotic edema, drug and serum reactions, anogenital pruritus and pruritus of chickenpox, as well as certain types of vascular headaches.


Cyproheptadine may be used as therapy for anaphylactic reactions, adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.


Cyproheptadine has been reported to have a beneficial effect in many patients diagnosed as having vascular types of headaches, such as migraine and histamine cephalalgia. Patients who have not been able to obtain adequate relief from any other agent have reported amelioration of symptoms with cyproheptadine. The characteristic headache and feeling of malaise may disappear within an hour or two after the first dose.


Contraindications: Although peripheral anticholinergic effects are minimal with recommended doses, as with all anticholinergic agents, cyproheptadine is contraindicated in patients with angle-closure glaucoma, in patients predisposed to urinary retention, and in patients with stenosing peptic ulcer or pyloroduodenal obstruction, symptomatic prostatic hypertrophy or bladder neck obstruction.


It is also contraindicated with concurrent MAO inhibitor therapy and in patients allergic to cyproheptadine.


Geriatrics: This drug should not be prescribed for elderly debilitated patients.


Lactation and Children: Antihistamines should not be used in nursing mothers, or in newborn or premature infants.


In an acute asthmatic attack, cyproheptadine should not be used.


Precautions: Antihistamines should not be used to treat lower respiratory tract symptoms including those of acute asthma.


Children: Safety and effectiveness in children below the age of 2 years have not been established.


Overdosage of antihistamines, particularly in infants and children, may produce hallucinations, CNS depression, convulsions, respiratory and cardiac arrest, and death.

Antihistamines may diminish mental alertness; conversely, particularly in the young child, they may occasionally produce excitation.


Occupational Hazards: This drug may impair alertness in some patients. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery. Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly patients.

Although not reported with cyproheptadine, rarely, prolonged therapy with antihistamines may cause blood dyscrasias.


Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with: history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension.

Pregnancy: The use of any drug in pregnancy, lactation, or in women of childbearing age requires that the potential benefits be weighed against its possible hazards to mother and child. Lactation may be inhibited.

The safe use of this drug in pregnancy has not been established.

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